The panel promise to have lots of lunchtime laughs as they debate and discuss the hottest topics of the day.
Ahead of the daytime talk show, Denise gushed that she is excited to 'mix it up' with 'two generations of the modern man' sharing their views on the topics.
The former Coronation Street actress said: 'We're delighted to be able to mix it up with a special Loose Women & Men episode, it'll be a hoot with us all on a panel together!
Mixing it up! ITV have announced that Loose Women & Men is back, with a new episode set to air this Thursday
'It'll be a hoot!' Regular panellists Judi Love , 43, and Denise Welch , 65, will be joined in the studio by Love Island's Iain Stirling , 35, and Good Morning Britain 's Richard Madeley , 67
'Richard and Iain are two generations of the modern man and we can't wait to hear their takes on some classic Loose topics in the studio.'
The special episode comes after Loose Women viewers called for Loose Men to become a regular part of the show after an all-male panel featured on the show last year.
The ITV series occasionally features a male panel with on episode last year featuring Andi Peters, Jordan Banjo, Ore Oduba and Shaun Wallace.
The all-black panel - who appeared during Black History Month last October - discussed issues such as body dysmorphia and the last time they cried during the episode, with many viewers calling for men to appear more frequently on the programme.
One viewer said: '#LooseMen should be a regular weekly agenda. Maybe once a week, men's opinions / perspectives count too!'
Another wrote: '#LooseMen should be on every day for me please.. far better God love them xx'.
One viewer added: 'I am loving #LooseMen today. I wish we could have this show every Friday or one evening a week to keep allowing men to nroamlise conversations to have a place to have them'.
Another wrote: 'ITV should definitely make #LooseMen a regular thing, I love it!'
Amazing: The panel promise to have lots of lunchtime laughs as they debate and discuss the hottest topics of the day
Denise hit the stage and pouted to the crowd while her co-stars sat with Martini glasses on the desk.
Jane, 61, was going for gold in a dazzling glittery dress and platforms while Linda, 65, meant business in a velvet suit with a glittery top.
Charlene, 43, was worlds away from her news anchor look, as she wowed in a sequinned green dress with a dramatic black bow at the neck and a slash at the leg.
Linda and Charlene put on an energetic display as they danced around the stage together in peels of laughter before the group posed together backstage.
Meanwhile on Friday, Frankie Bridge and Christine Lampard put on a sensational display as they led the departures at The Loose Women Live Tour.
The former The Saturdays singer, 34, and TV presenter, 44, both opted for black for the trendy event at The Opera House Theatre in Manchester.
The pair posed up a storm as they were mobbed for selfies and autographs as they left the Opera House Theatre in Manchester.
In demand: The special episode comes after Loose Women viewers called for Loose Men to become a regular part of the show after an all-male panel featured on the show last year
Swapping the studio for the stage, ITV promise Loose Women Live to be an evening 'filled with laughter, hot topics, fun and surprises'.
It's the first-ever live show where different line ups of the iconic panel share their stories and secrets live and in person up and down the country.
Star guests will feature over the shows including EastEnders and Gavin And Stacey favourite Larry Lamb, Emmerdale actress Charlie Hardwick, X Factor winner Sam Bailey and more.
Joining the crew is Gloria Hunniford, Jane Moore, Janet Street-Porter, Judi Love, Katie Piper, Kaye Adams, Kelle Bryan, Nadia Sawalha and Sunetra Sarker.
The live show is presented by Cuffe and Taylor (Live Nation) and Lambert Jackson in partnership with ITV.
Loose Women & Men will air on Thursday 14th September from 12:30pm on ITV1 & ITVX